**Isaiah Pacheco’s Status Uncertain**: Kansas City Chiefs head coach Andy Reid announced that running back Isaiah Pacheco is unlikely to play this Sunday despite returning to practice.

**Buffalo Bills Face Injury Challenges**: Wide receiver Amari Cooper is recovering from a wrist injury and was limited in practice, while tight end Dalton Kincaid did not practice due to a knee injury. Rookie wide receiver Keon Coleman has already been ruled out.

**Playoff Implications for Chiefs and Bills**: A victory for the Chiefs would give them a 93% chance of securing the top seed in the playoffs, while a Bills win would drop the Chiefs’ chances to 55%.

**Josh Allen and Patrick Mahomes Anticipate Competitive Matchup**: Both quarterbacks acknowledge the significance of their rivalry, with Allen emphasizing the need for their best performance to win.

**Key Strategies for Bills to Win**: Analysts suggest that the Bills must apply edge pressure on the Chiefs’ tackles, utilize quick passes to Khalil Shakir, and excel in the red zone to limit the Chiefs to field goals.

**Chiefs’ Offensive Strategy**: The Chiefs are noted for their balanced offensive approach, focusing on efficiency rather than explosive plays, which allows them to control the game clock.

**Bills’ Defensive Preparation**: The Bills’ defense, familiar with the Chiefs’ style, aims to contain Patrick Mahomes, emphasizing the importance of red zone defense in their game plan.